Assay Detail
Binding
CHEMBL4186813
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Inhibition of CYP19A1 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.30 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446083 | — | — | 1 | 7.00 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 6.10 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 5.80 |
| CHEMBL4207995 | — | — | 1 | - |
| CHEMBL4212612 | — | — | 1 | - |
| CHEMBL4211193 | — | — | 1 | - |
| CHEMBL4212918 | — | — | 1 | - |
| CHEMBL4214618 | — | — | 1 | - |
| CHEMBL4207348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446083 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4207995 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4212612 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4211193 | — | IC50 | > | 19952.62 | nM | - |
| CHEMBL4212918 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4214618 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4207348 | — | IC50 | > | 19952.62 | nM | - |