Assay Detail
Binding
CHEMBL4186853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FITC-MBM1 from full length human menin measured after 2 hrs by fluorescence polarization assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.12 | 6.08 |
| Ki | 1 | 7.10 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216333 | — | — | 2 | 7.10 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216333 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL4216333 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL841 | LOPERAMIDE | IC50 | = | 69000.0 | nM | 4.16 |