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Assay Detail

CHEMBL4186854

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Functional
Antagonist activity at P2Y1 receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 1 (CHEMBL4315)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Current knowledge on the nucleotide agonists for the P2Y2 receptor.
Xu P, Feng X, Luan H, Wang J, Ge R, Li Z, Bian J.
Bioorg Med Chem (2018) 26 : 366 -375
PubMed 29254895 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.86 7.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2112864 1 7.28
CHEMBL4214232 1 6.83
CHEMBL129841 1 6.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2112864 IC50 = 52.0 nM 7.28
CHEMBL4214232 IC50 = 148.0 nM 6.83
CHEMBL129841 IC50 = 330.0 nM 6.48