Assay Detail
Binding
CHEMBL4187356
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Inhibition of alpha-glucosidase (unknown origin) using PNP-G as substrate measured for 15 mins by spectrophotometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.82 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260553 | — | — | 1 | 5.77 |
| CHEMBL4211682 | — | — | 1 | 5.32 |
| CHEMBL323197 | MANGOSTIN | — | 1 | 5.24 |
| CHEMBL4203265 | — | — | 1 | 5.00 |
| CHEMBL4202640 | — | — | 1 | 4.86 |
| CHEMBL4208135 | — | — | 1 | 4.79 |
| CHEMBL1782241 | COCHINCHINONE A | — | 1 | 4.76 |
| CHEMBL4209191 | — | — | 1 | 4.69 |
| CHEMBL1782240 | — | — | 1 | 4.59 |
| CHEMBL4214309 | — | — | 1 | 4.55 |
| CHEMBL4217516 | — | — | 1 | 4.51 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 4.40 |
| CHEMBL4218731 | — | — | 1 | 4.14 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260553 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4211682 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL323197 | MANGOSTIN | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4203265 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4202640 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4208135 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1782241 | COCHINCHINONE A | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4209191 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL1782240 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL4214309 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL4217516 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4218731 | — | IC50 | = | 72700.0 | nM | 4.14 |
| CHEMBL169 | URSOLIC ACID | IC50 | - | — | - |