Assay Detail
Binding
CHEMBL4187413
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Inhibition of HDAC6 (unknown origin) preincubated for 10 mins followed by Ac-Leu-GlyLys(Ac)-AMC substrate addition measured after 30 mins by fluorescence based assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.07 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 8.28 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.06 |
| CHEMBL4211463 | — | — | 1 | 7.48 |
| CHEMBL4203874 | — | — | 1 | 7.47 |
| CHEMBL4211477 | — | — | 1 | 7.42 |
| CHEMBL4204972 | — | — | 1 | 7.40 |
| CHEMBL4217830 | — | — | 1 | 7.39 |
| CHEMBL4205573 | — | — | 1 | 7.24 |
| CHEMBL4217618 | — | — | 1 | 7.23 |
| CHEMBL4214775 | — | — | 1 | 7.19 |
| CHEMBL4212669 | — | — | 1 | 7.19 |
| CHEMBL4212219 | — | — | 1 | 7.16 |
| CHEMBL4208584 | — | — | 1 | 7.11 |
| CHEMBL4203741 | — | — | 1 | 7.01 |
| CHEMBL4205375 | — | — | 1 | 6.99 |
| CHEMBL4214652 | — | — | 1 | 6.88 |
| CHEMBL4213207 | — | — | 1 | 6.83 |
| CHEMBL4208276 | — | — | 1 | 6.80 |
| CHEMBL4207699 | — | — | 1 | 6.75 |
| CHEMBL4210396 | — | — | 1 | 6.66 |
| CHEMBL4210899 | — | — | 1 | 6.62 |
| CHEMBL4210578 | — | — | 1 | 6.60 |
| CHEMBL4217088 | — | — | 1 | 6.55 |
| CHEMBL4203935 | — | — | 1 | 6.53 |
| CHEMBL4202659 | — | — | 1 | 6.46 |
| CHEMBL4215505 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4211463 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4203874 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4211477 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4204972 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4217830 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4205573 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4217618 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4214775 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4212669 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4212219 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4208584 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4203741 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4205375 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4214652 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4213207 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4208276 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4207699 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4210396 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4210899 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL4210578 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4217088 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL4203935 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL4202659 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL4215505 | — | IC50 | = | 385.0 | nM | 6.42 |