Assay Detail
Functional
CHEMBL4187414
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Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.21 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076610 | — | — | 1 | 7.39 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 5.85 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.57 |
| CHEMBL4203874 | — | — | 1 | 5.05 |
| CHEMBL4211463 | — | — | 1 | 4.82 |
| CHEMBL4217830 | — | — | 1 | 4.66 |
| CHEMBL4217618 | — | — | 1 | 4.64 |
| CHEMBL4204972 | — | — | 1 | 4.55 |
| CHEMBL4214775 | — | — | 1 | 4.35 |
| CHEMBL4214652 | — | — | 1 | - |
| CHEMBL4210396 | — | — | 1 | - |
| CHEMBL4202659 | — | — | 1 | - |
| CHEMBL4208584 | — | — | 1 | - |
| CHEMBL4211477 | — | — | 1 | - |
| CHEMBL4203741 | — | — | 1 | - |
| CHEMBL4208276 | — | — | 1 | - |
| CHEMBL4210899 | — | — | 1 | - |
| CHEMBL4203935 | — | — | 1 | - |
| CHEMBL4207699 | — | — | 1 | - |
| CHEMBL4217088 | — | — | 1 | - |
| CHEMBL4205375 | — | — | 1 | - |
| CHEMBL4212669 | — | — | 1 | - |
| CHEMBL4215505 | — | — | 1 | - |
| CHEMBL4212219 | — | — | 1 | - |
| CHEMBL4210578 | — | — | 1 | - |
| CHEMBL4205573 | — | — | 1 | - |
| CHEMBL4213207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076610 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4203874 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4211463 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4217830 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4217618 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4204972 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4214775 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4214652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4210396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4202659 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4208584 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4211477 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4203741 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4208276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4210899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4203935 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4207699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4217088 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4205375 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4212669 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215505 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4212219 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4210578 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4205573 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4213207 | — | IC50 | > | 100000.0 | nM | - |