Assay Detail
Functional
CHEMBL4187424
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Antiproliferative activity against human RPMI8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by Cell-titer-Glo luminescent cell viability assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.94 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205779 | — | — | 1 | 5.87 |
| CHEMBL4212641 | — | — | 1 | 5.75 |
| CHEMBL4217448 | — | — | 1 | 4.93 |
| CHEMBL4216304 | — | — | 1 | 4.91 |
| CHEMBL4205084 | — | — | 1 | 4.81 |
| CHEMBL4213102 | — | — | 1 | 4.69 |
| CHEMBL4206833 | — | — | 1 | 4.67 |
| CHEMBL4204402 | — | — | 1 | 4.61 |
| CHEMBL4209151 | — | — | 1 | 4.58 |
| CHEMBL4215514 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205779 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4212641 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4217448 | — | IC50 | = | 11660.0 | nM | 4.93 |
| CHEMBL4216304 | — | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL4205084 | — | IC50 | = | 15510.0 | nM | 4.81 |
| CHEMBL4213102 | — | IC50 | = | 20460.0 | nM | 4.69 |
| CHEMBL4206833 | — | IC50 | = | 21520.0 | nM | 4.67 |
| CHEMBL4204402 | — | IC50 | = | 24680.0 | nM | 4.61 |
| CHEMBL4209151 | — | IC50 | = | 26580.0 | nM | 4.58 |
| CHEMBL4215514 | — | IC50 | = | 29150.0 | nM | 4.54 |