Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4187625

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL2409)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD.
Bioorg Med Chem Lett (2018) 28 : 762 -768
PubMed 29366648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 8.29 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2397148 1 9.10
CHEMBL4206149 1 8.70
CHEMBL1552108 1 8.70
CHEMBL4216368 1 8.70
CHEMBL4207039 1 8.70
CHEMBL4211037 1 8.70
CHEMBL2397138 1 8.70
CHEMBL4211405 1 8.52
CHEMBL4215208 1 8.52
CHEMBL4203223 1 8.52
CHEMBL4209593 1 8.52
CHEMBL242459 1 8.52
CHEMBL4204023 1 8.40
CHEMBL4214874 1 8.40
CHEMBL4211919 1 8.40
CHEMBL4213817 1 8.30
CHEMBL4214503 1 8.30
CHEMBL3677989 1 8.30
CHEMBL4217146 1 8.22
CHEMBL4212165 1 8.15
CHEMBL4203466 1 8.15
CHEMBL4205926 1 8.15
CHEMBL4208326 1 8.10
CHEMBL4214601 1 7.82
CHEMBL4204930 1 7.75
CHEMBL4216616 1 7.52
CHEMBL184238 URB-597 1.0 1 5.96
CHEMBL4204424 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2397148 IC50 = 0.8 nM 9.10
CHEMBL4206149 IC50 = 2.0 nM 8.70
CHEMBL1552108 IC50 = 2.0 nM 8.70
CHEMBL4216368 IC50 = 2.0 nM 8.70
CHEMBL4207039 IC50 = 2.0 nM 8.70
CHEMBL4211037 IC50 = 2.0 nM 8.70
CHEMBL2397138 IC50 = 2.0 nM 8.70
CHEMBL4211405 IC50 = 3.0 nM 8.52
CHEMBL4215208 IC50 = 3.0 nM 8.52
CHEMBL4203223 IC50 = 3.0 nM 8.52
CHEMBL4209593 IC50 = 3.0 nM 8.52
CHEMBL242459 IC50 = 3.0 nM 8.52
CHEMBL4204023 IC50 = 4.0 nM 8.40
CHEMBL4214874 IC50 = 4.0 nM 8.40
CHEMBL4211919 IC50 = 4.0 nM 8.40
CHEMBL4213817 IC50 = 5.0 nM 8.30
CHEMBL4214503 IC50 = 5.0 nM 8.30
CHEMBL3677989 IC50 = 5.0 nM 8.30
CHEMBL4217146 IC50 = 6.0 nM 8.22
CHEMBL4212165 IC50 = 7.0 nM 8.15
CHEMBL4203466 IC50 = 7.0 nM 8.15
CHEMBL4205926 IC50 = 7.0 nM 8.15
CHEMBL4208326 IC50 = 8.0 nM 8.10
CHEMBL4214601 IC50 = 15.0 nM 7.82
CHEMBL4204930 IC50 = 18.0 nM 7.75
CHEMBL4216616 IC50 = 30.0 nM 7.52
CHEMBL184238 URB-597 IC50 = 1100.0 nM 5.96
CHEMBL4204424 IC50 > 10000.0 nM -