Assay Detail
Binding
CHEMBL4187828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin production by enzyme immunoassay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.89 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205552 | — | — | 1 | 7.40 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.82 |
| CHEMBL4212341 | — | — | 1 | 6.80 |
| CHEMBL4210463 | — | — | 1 | 6.36 |
| CHEMBL4210856 | — | — | 1 | 6.34 |
| CHEMBL4215506 | — | — | 1 | 6.03 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.97 |
| CHEMBL4203006 | — | — | 1 | 5.92 |
| CHEMBL4204840 | — | — | 1 | 5.86 |
| CHEMBL4211316 | — | — | 1 | 5.86 |
| CHEMBL4212465 | — | — | 1 | 5.85 |
| CHEMBL4208086 | — | — | 1 | 5.81 |
| CHEMBL4212716 | — | — | 1 | 5.65 |
| CHEMBL4206180 | — | — | 1 | 5.57 |
| CHEMBL4213903 | — | — | 1 | 5.32 |
| CHEMBL4202666 | — | — | 1 | 5.13 |
| CHEMBL4216007 | — | — | 1 | 4.97 |
| CHEMBL4209915 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205552 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL118 | CELECOXIB | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4212341 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4210463 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4210856 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4215506 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4203006 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4204840 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4211316 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4212465 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4208086 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4212716 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4206180 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4213903 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4202666 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4216007 | — | IC50 | = | 10590.0 | nM | 4.97 |
| CHEMBL4209915 | — | IC50 | = | 45540.0 | nM | 4.34 |