Assay Detail
Functional
CHEMBL4187883
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Growth inhibition of human KG1a cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1a |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.96 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218857 | — | — | 1 | 7.30 |
| CHEMBL4212782 | — | — | 1 | 6.96 |
| CHEMBL4216514 | — | — | 1 | 6.85 |
| CHEMBL4203317 | — | — | 1 | 6.82 |
| CHEMBL4216757 | — | — | 1 | 6.60 |
| CHEMBL4203895 | — | — | 1 | 6.50 |
| CHEMBL4213925 | — | — | 1 | 6.35 |
| CHEMBL4203106 | — | — | 1 | 6.17 |
| CHEMBL4207009 | — | — | 1 | 5.71 |
| CHEMBL4209850 | — | — | 1 | 5.69 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.05 |
| CHEMBL4216010 | — | — | 1 | 5.01 |
| CHEMBL4217670 | — | — | 1 | 4.89 |
| CHEMBL4212055 | — | — | 1 | 4.87 |
| CHEMBL4210740 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218857 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4212782 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4216514 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4203317 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4216757 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4203895 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4213925 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4203106 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4207009 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4209850 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL4216010 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL4217670 | — | IC50 | = | 12880.0 | nM | 4.89 |
| CHEMBL4212055 | — | IC50 | = | 13560.0 | nM | 4.87 |
| CHEMBL4210740 | — | IC50 | = | 25390.0 | nM | 4.59 |