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Assay Detail

CHEMBL4188420

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Binding
Inhibition of HCV genotype 1b NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay
ChEMBL ↗
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 1b
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

RNA-directed RNA polymerase (CHEMBL4296320) ↗
Type SINGLE PROTEIN
Organism Hepacivirus hominis

Publication

Discovery of novel potent HCV NS5B polymerase non-nucleoside inhibitors bearing a fused benzofuran scaffold.
Zhong M, Peng E, Huang N, Huang Q, Huq A, Lau M, Colonno R, Li L.
Bioorg Med Chem Lett (2018) 28 : 963 -968
PubMed 29422387 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 71 7.54 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4212080 — — 1 8.52
CHEMBL4206116 — — 1 8.52
CHEMBL4214242 — — 1 8.52
CHEMBL4212453 — — 1 8.52
CHEMBL4204025 — — 1 8.52
CHEMBL4215104 — — 1 8.40
CHEMBL4209098 — — 1 8.30
CHEMBL4208651 — — 1 8.30
CHEMBL4213601 — — 1 8.30
CHEMBL4217837 — — 1 8.22
CHEMBL4214099 — — 1 8.15
CHEMBL4211784 — — 1 8.15
CHEMBL4213364 — — 1 8.15
CHEMBL4218295 — — 1 8.10
CHEMBL4208088 — — 1 8.10
CHEMBL4212138 — — 1 8.05
CHEMBL4210478 — — 1 7.96
CHEMBL4207194 — — 1 7.96
CHEMBL1092581 NESBUVIR 2.0 1 7.92
CHEMBL4208902 — — 1 7.92
CHEMBL4213298 — — 1 7.89
CHEMBL4217481 — — 1 7.89
CHEMBL4213964 — — 1 7.89
CHEMBL4216751 — — 1 7.89
CHEMBL4209204 — — 1 7.85
CHEMBL4213893 — — 1 7.85
CHEMBL4204337 — — 1 7.82
CHEMBL4218571 — — 1 7.80
CHEMBL4209040 — — 1 7.77
CHEMBL4218648 — — 1 7.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4212080 — EC50 = 3.0 nM 8.52
CHEMBL4204025 — EC50 = 3.0 nM 8.52
CHEMBL4212453 — EC50 = 3.0 nM 8.52
CHEMBL4206116 — EC50 = 3.0 nM 8.52
CHEMBL4214242 — EC50 = 3.0 nM 8.52
CHEMBL4215104 — EC50 = 4.0 nM 8.40
CHEMBL4209098 — EC50 = 5.0 nM 8.30
CHEMBL4208651 — EC50 = 5.0 nM 8.30
CHEMBL4213601 — EC50 = 5.0 nM 8.30
CHEMBL4217837 — EC50 = 6.0 nM 8.22
CHEMBL4214099 — EC50 = 7.0 nM 8.15
CHEMBL4211784 — EC50 = 7.0 nM 8.15
CHEMBL4213364 — EC50 = 7.0 nM 8.15
CHEMBL4208088 — EC50 = 8.0 nM 8.10
CHEMBL4218295 — EC50 = 8.0 nM 8.10
CHEMBL4212138 — EC50 = 9.0 nM 8.05
CHEMBL4210478 — EC50 = 11.0 nM 7.96
CHEMBL4207194 — EC50 = 11.0 nM 7.96
CHEMBL1092581 NESBUVIR EC50 = 12.0 nM 7.92
CHEMBL4208902 — EC50 = 12.0 nM 7.92
CHEMBL4213298 — EC50 = 13.0 nM 7.89
CHEMBL4217481 — EC50 = 13.0 nM 7.89
CHEMBL4213964 — EC50 = 13.0 nM 7.89
CHEMBL4216751 — EC50 = 13.0 nM 7.89
CHEMBL4213893 — EC50 = 14.0 nM 7.85
CHEMBL4209204 — EC50 = 14.0 nM 7.85
CHEMBL4204337 — EC50 = 15.0 nM 7.82
CHEMBL4218571 — EC50 = 16.0 nM 7.80
CHEMBL4209040 — EC50 = 17.0 nM 7.77
CHEMBL4218648 — EC50 = 17.0 nM 7.77
CHEMBL4203973 — EC50 = 19.0 nM 7.72
CHEMBL4206056 — EC50 = 19.0 nM 7.72
CHEMBL4207254 — EC50 = 20.0 nM 7.70
CHEMBL4205541 — EC50 = 24.0 nM 7.62
CHEMBL4203126 — EC50 = 26.0 nM 7.58
CHEMBL4211202 — EC50 = 26.0 nM 7.58
CHEMBL4208697 — EC50 = 31.0 nM 7.51
CHEMBL4211447 — EC50 = 33.0 nM 7.48
CHEMBL4205607 — EC50 = 38.0 nM 7.42
CHEMBL4216526 — EC50 = 43.0 nM 7.37
CHEMBL4212819 — EC50 = 46.0 nM 7.34
CHEMBL4208977 — EC50 = 56.0 nM 7.25
CHEMBL4213434 — EC50 = 59.0 nM 7.23
CHEMBL4216234 — EC50 = 69.0 nM 7.16
CHEMBL4204771 — EC50 = 73.0 nM 7.14
CHEMBL4218362 — EC50 = 74.0 nM 7.13
CHEMBL4210678 — EC50 = 78.0 nM 7.11
CHEMBL4214423 — EC50 = 107.0 nM 6.97
CHEMBL4209493 — EC50 = 109.0 nM 6.96
CHEMBL4206315 — EC50 = 164.0 nM 6.79