Assay Detail
Binding
CHEMBL4188426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 2a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Discovery of novel potent HCV NS5B polymerase non-nucleoside inhibitors bearing a fused benzofuran scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.28 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204025 | — | — | 1 | 7.92 |
| CHEMBL4214242 | — | — | 1 | 7.75 |
| CHEMBL4208902 | — | — | 1 | 7.21 |
| CHEMBL4211784 | — | — | 1 | 7.19 |
| CHEMBL1092581 | NESBUVIR | 2.0 | 1 | 7.14 |
| CHEMBL4206056 | — | — | 1 | 6.87 |
| CHEMBL4211447 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204025 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4214242 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4208902 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4211784 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1092581 | NESBUVIR | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4206056 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4211447 | — | EC50 | = | 141.0 | nM | 6.85 |