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Assay Detail

CHEMBL4188511

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant His-tagged MIF tautomerase activity (unknown origin) using 4-HPP as substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Macrophage migration inhibitory factor (CHEMBL2085)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.
Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ.
Bioorg Med Chem (2018) 26 : 999 -1005
PubMed 29428527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.84 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4207747 1 5.21
CHEMBL4209531 1 5.15
CHEMBL4217822 1 5.10
CHEMBL4211777 1 4.89
CHEMBL4204904 1 4.75
CHEMBL4217708 1 4.68
CHEMBL210858 1 4.10
CHEMBL4209885 1 -
CHEMBL4210876 1 -
CHEMBL4218300 1 -
CHEMBL4217815 1 -
CHEMBL4208404 1 -
CHEMBL4206221 1 -
CHEMBL4207466 1 -
CHEMBL4214641 1 -
CHEMBL4202647 1 -
CHEMBL4214173 1 -
CHEMBL4208075 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4207747 IC50 = 6200.0 nM 5.21
CHEMBL4209531 IC50 = 7100.0 nM 5.15
CHEMBL4217822 IC50 = 8000.0 nM 5.10
CHEMBL4211777 IC50 = 13000.0 nM 4.89
CHEMBL4204904 IC50 = 18000.0 nM 4.75
CHEMBL4217708 IC50 = 21000.0 nM 4.68
CHEMBL210858 IC50 = 79000.0 nM 4.10
CHEMBL4209885 IC50 - -
CHEMBL4210876 IC50 - -
CHEMBL4218300 IC50 - -
CHEMBL4217815 IC50 - -
CHEMBL4208404 IC50 - -
CHEMBL4206221 IC50 - -
CHEMBL4207466 IC50 - -
CHEMBL4214641 IC50 - -
CHEMBL4202647 IC50 - -
CHEMBL4214173 IC50 - -
CHEMBL4208075 IC50 - -