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Assay Detail

CHEMBL4188872

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Binding
Binding affinity to Pseudomonas aeruginosa HemO by intrinsic fluorescence quenching assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Heme oxygenase (CHEMBL1075209)
Type SINGLE PROTEIN
Organism Pseudomonas aeruginosa

Publication

Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO).
Liang D, Robinson E, Hom K, Yu W, Nguyen N, Li Y, Zong Q, Wilks A, Xue F.
Bioorg Med Chem Lett (2018) 28 : 1024 -1029
PubMed 29459206 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 30 4.92 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4211139 1 5.96
CHEMBL4205009 1 5.92
CHEMBL4206766 1 5.64
CHEMBL4213232 1 5.48
CHEMBL4214701 1 5.41
CHEMBL4208245 1 5.28
CHEMBL4216690 1 5.19
CHEMBL4208843 1 5.19
CHEMBL4207894 1 5.19
CHEMBL4218166 1 5.16
CHEMBL4204511 1 5.13
CHEMBL4215087 1 5.12
CHEMBL4205928 1 5.00
CHEMBL402263 1 4.89
CHEMBL4216107 1 4.89
CHEMBL4210810 1 4.85
CHEMBL4216670 1 4.82
CHEMBL4211173 1 4.75
CHEMBL4213769 1 4.70
CHEMBL3597542 1 4.64
CHEMBL4203023 1 4.60
CHEMBL4218632 1 4.58
CHEMBL4209679 1 4.57
CHEMBL4209382 1 4.55
CHEMBL4213702 1 4.42
CHEMBL4203370 1 4.37
CHEMBL4212904 1 4.36
CHEMBL4214218 1 4.35
CHEMBL4218086 1 4.29
CHEMBL2011392 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4211139 Kd = 1100.0 nM 5.96
CHEMBL4205009 Kd = 1200.0 nM 5.92
CHEMBL4206766 Kd = 2300.0 nM 5.64
CHEMBL4213232 Kd = 3300.0 nM 5.48
CHEMBL4214701 Kd = 3900.0 nM 5.41
CHEMBL4208245 Kd = 5200.0 nM 5.28
CHEMBL4216690 Kd = 6500.0 nM 5.19
CHEMBL4208843 Kd = 6400.0 nM 5.19
CHEMBL4207894 Kd = 6500.0 nM 5.19
CHEMBL4218166 Kd = 7000.0 nM 5.16
CHEMBL4204511 Kd = 7400.0 nM 5.13
CHEMBL4215087 Kd = 7600.0 nM 5.12
CHEMBL4205928 Kd = 10000.0 nM 5.00
CHEMBL402263 Kd = 13000.0 nM 4.89
CHEMBL4216107 Kd = 13000.0 nM 4.89
CHEMBL4210810 Kd = 14000.0 nM 4.85
CHEMBL4216670 Kd = 15000.0 nM 4.82
CHEMBL4211173 Kd = 18000.0 nM 4.75
CHEMBL4213769 Kd = 20000.0 nM 4.70
CHEMBL3597542 Kd = 23000.0 nM 4.64
CHEMBL4203023 Kd = 25000.0 nM 4.60
CHEMBL4218632 Kd = 26000.0 nM 4.58
CHEMBL4209679 Kd = 27000.0 nM 4.57
CHEMBL4209382 Kd = 28000.0 nM 4.55
CHEMBL4213702 Kd = 38000.0 nM 4.42
CHEMBL4203370 Kd = 43000.0 nM 4.37
CHEMBL4212904 Kd = 44000.0 nM 4.36
CHEMBL4214218 Kd = 45000.0 nM 4.35
CHEMBL4218086 Kd = 51000.0 nM 4.29
CHEMBL2011392 Kd = 57000.0 nM 4.24