Assay Detail
Binding
CHEMBL4188976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type human partial length SRC (L240 to L536 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substrate in presence of [gamma-33P]ATP
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.03 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 7.43 |
| CHEMBL4218175 | — | — | 1 | 7.03 |
| CHEMBL4208852 | — | — | 1 | 6.10 |
| CHEMBL4214476 | — | — | 1 | 6.05 |
| CHEMBL4210084 | — | — | 1 | 6.00 |
| CHEMBL4213003 | — | — | 1 | 5.96 |
| CHEMBL4213775 | — | — | 1 | 5.44 |
| CHEMBL4209569 | — | — | 1 | 5.14 |
| CHEMBL4218369 | — | — | 1 | 5.08 |
| CHEMBL4204515 | — | — | 1 | - |
| CHEMBL4207004 | — | — | 1 | - |
| CHEMBL4217649 | — | — | 1 | - |
| CHEMBL4211308 | — | — | 1 | - |
| CHEMBL4205191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4218175 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4208852 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4214476 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4210084 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4213003 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4213775 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4209569 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4218369 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4204515 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4207004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4217649 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4211308 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4205191 | — | IC50 | > | 10000.0 | nM | - |