Assay Detail
Binding
CHEMBL4189162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human N-terminal alphaHis-SUMO-tagged ERRgamma-LBD (229 to 458 residues) expressed in Escherichia coli BL21 gold (DE3) cells assessed as decrease in RIP140 peptide recruitment after 2 hrs by TR-FRET assay
78
Total Activities
78
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 78 | 5.69 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204173 | — | — | 1 | 7.08 |
| CHEMBL4205664 | — | — | 1 | 6.41 |
| CHEMBL193836 | — | — | 1 | 6.22 |
| CHEMBL4204689 | — | — | 1 | 6.16 |
| CHEMBL4206963 | — | — | 1 | 6.12 |
| CHEMBL4207558 | — | — | 1 | 6.09 |
| CHEMBL4211789 | — | — | 1 | 6.02 |
| CHEMBL4217033 | — | — | 1 | 6.02 |
| CHEMBL4209406 | — | — | 1 | 5.94 |
| CHEMBL4210295 | — | — | 1 | 5.89 |
| CHEMBL4208749 | — | — | 1 | 5.70 |
| CHEMBL4203030 | — | — | 1 | 5.64 |
| CHEMBL4216299 | — | — | 1 | 5.52 |
| CHEMBL4205820 | — | — | 1 | 5.50 |
| CHEMBL4208949 | — | — | 1 | 5.46 |
| CHEMBL4217743 | — | — | 1 | 5.37 |
| CHEMBL4218028 | — | — | 1 | 5.36 |
| CHEMBL4202808 | — | — | 1 | 5.28 |
| CHEMBL4212795 | — | — | 1 | 5.23 |
| CHEMBL4211333 | — | — | 1 | 5.21 |
| CHEMBL4206438 | — | — | 1 | 5.16 |
| CHEMBL4213990 | — | — | 1 | 5.12 |
| CHEMBL4207869 | — | — | 1 | 5.05 |
| CHEMBL4212497 | — | — | 1 | 5.04 |
| CHEMBL4210685 | — | — | 1 | - |
| CHEMBL4216915 | — | — | 1 | - |
| CHEMBL4209589 | — | — | 1 | - |
| CHEMBL396869 | — | — | 1 | - |
| CHEMBL396870 | — | — | 1 | - |
| CHEMBL3302645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204173 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4205664 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL193836 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4204689 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4206963 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4207558 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4211789 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4217033 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4209406 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4210295 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4208749 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4203030 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4216299 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4205820 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4208949 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4217743 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4218028 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4202808 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4212795 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4211333 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4206438 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4213990 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4207869 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4212497 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4216312 | — | EC50 | - | — | - | |
| CHEMBL4205207 | — | EC50 | - | — | - | |
| CHEMBL4206568 | — | EC50 | - | — | - | |
| CHEMBL4212179 | — | EC50 | - | — | - | |
| CHEMBL4217160 | — | EC50 | - | — | - | |
| CHEMBL4203591 | — | EC50 | - | — | - | |
| CHEMBL4203210 | — | EC50 | - | — | - | |
| CHEMBL4218741 | — | EC50 | - | — | - | |
| CHEMBL4208494 | — | EC50 | - | — | - | |
| CHEMBL4204076 | — | EC50 | - | — | - | |
| CHEMBL4216278 | — | EC50 | - | — | - | |
| CHEMBL4213794 | — | EC50 | - | — | - | |
| CHEMBL4212467 | — | EC50 | - | — | - | |
| CHEMBL4203460 | — | EC50 | - | — | - | |
| CHEMBL4212018 | — | EC50 | - | — | - | |
| CHEMBL4215061 | — | EC50 | - | — | - | |
| CHEMBL4213472 | — | EC50 | - | — | - | |
| CHEMBL4211327 | — | EC50 | - | — | - | |
| CHEMBL4211525 | — | EC50 | - | — | - | |
| CHEMBL4203867 | — | EC50 | - | — | - | |
| CHEMBL3302645 | — | EC50 | - | — | - | |
| CHEMBL396870 | — | EC50 | - | — | - | |
| CHEMBL396869 | — | EC50 | - | — | - | |
| CHEMBL4209589 | — | EC50 | - | — | - | |
| CHEMBL4216915 | — | EC50 | - | — | - | |
| CHEMBL4210685 | — | EC50 | - | — | - |