Assay Detail
Binding
CHEMBL4189167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at human N-terminal alphaHis-SUMO-tagged ERRgamma-LBD (229 to 458 residues) expressed in Escherichia coli BL21 gold (DE3) cells assessed as decrease in RIP140 peptide recruitment after 2 hrs by TR-FRET assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.75 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204610 | — | — | 1 | 6.68 |
| CHEMBL4211016 | — | — | 1 | 6.52 |
| CHEMBL4204153 | — | — | 1 | 6.09 |
| CHEMBL4209143 | — | — | 1 | 5.77 |
| CHEMBL4217256 | — | — | 1 | 5.67 |
| CHEMBL4216886 | — | — | 1 | 5.51 |
| CHEMBL4211906 | — | — | 1 | 5.22 |
| CHEMBL4206319 | — | — | 1 | 5.21 |
| CHEMBL4206727 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204610 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4211016 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4204153 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4209143 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4217256 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4216886 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4211906 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4206319 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4206727 | — | EC50 | = | 7900.0 | nM | 5.10 |