Assay Detail
Binding
CHEMBL4189170
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Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206963 | — | — | 1 | 7.70 |
| CHEMBL4217033 | — | — | 1 | 7.51 |
| CHEMBL4211016 | — | — | 1 | 7.35 |
| CHEMBL4204689 | — | — | 1 | 7.05 |
| CHEMBL4205664 | — | — | 1 | 6.20 |
| CHEMBL4211789 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4206963 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4217033 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4211016 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4204689 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4205664 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4211789 | — | EC50 | = | 2700.0 | nM | 5.57 |