Assay Detail
Functional
CHEMBL4189178
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Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enantiomeric neolignans from Picrasma quassioides exhibit distinctive cytotoxicity on hepatic carcinoma cells through ROS generation and apoptosis induction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.28 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406378 | — | — | 1 | 4.45 |
| CHEMBL468666 | — | — | 1 | 4.44 |
| CHEMBL253335 | — | — | 1 | 4.42 |
| CHEMBL1956166 | — | — | 1 | 4.41 |
| CHEMBL4163889 | — | — | 1 | 4.11 |
| CHEMBL4214916 | — | — | 1 | 4.09 |
| CHEMBL413991 | — | — | 1 | 4.05 |
| CHEMBL3753146 | — | — | 1 | - |
| CHEMBL1761712 | DEHYDROCONIFERYL ALCOHOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406378 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL468666 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL253335 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL1956166 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL4163889 | — | IC50 | = | 78600.0 | nM | 4.11 |
| CHEMBL4214916 | — | IC50 | = | 80500.0 | nM | 4.09 |
| CHEMBL413991 | — | IC50 | = | 88700.0 | nM | 4.05 |
| CHEMBL3753146 | — | IC50 | = | 104100.0 | nM | - |
| CHEMBL1761712 | DEHYDROCONIFERYL ALCOHOL | IC50 | = | 104400.0 | nM | - |