Assay Detail
Binding
CHEMBL4189207
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Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.44 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204681 | — | — | 1 | 7.05 |
| CHEMBL4213046 | — | — | 1 | 6.64 |
| CHEMBL1257064 | — | — | 1 | 6.50 |
| CHEMBL2324266 | — | — | 1 | 6.40 |
| CHEMBL1257114 | — | — | 1 | 6.38 |
| CHEMBL4212803 | — | — | 1 | 6.28 |
| CHEMBL1257089 | — | — | 1 | 6.26 |
| CHEMBL1257090 | — | — | 1 | 5.99 |
| CHEMBL4208290 | — | — | 1 | - |
| CHEMBL4215433 | — | — | 1 | - |
| CHEMBL4209726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204681 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4213046 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1257064 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2324266 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1257114 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4212803 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1257089 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1257090 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4208290 | — | IC50 | - | — | - | |
| CHEMBL4215433 | — | IC50 | - | — | - | |
| CHEMBL4209726 | — | IC50 | - | — | - |