Assay Detail
Binding
CHEMBL4189208
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Inhibition of full-length rat GST-tagged CK1delta using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.07 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215433 | — | — | 1 | 6.48 |
| CHEMBL4204681 | — | — | 1 | 6.39 |
| CHEMBL2324266 | — | — | 1 | 6.18 |
| CHEMBL4209726 | — | — | 1 | 6.16 |
| CHEMBL4213046 | — | — | 1 | 6.12 |
| CHEMBL1257064 | — | — | 1 | 6.03 |
| CHEMBL4208290 | — | — | 1 | 5.99 |
| CHEMBL1257090 | — | — | 1 | 5.97 |
| CHEMBL4212803 | — | — | 1 | 5.97 |
| CHEMBL1257114 | — | — | 1 | 5.78 |
| CHEMBL1257089 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215433 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4204681 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2324266 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4209726 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4213046 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1257064 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4208290 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1257090 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4212803 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1257114 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1257089 | — | IC50 | = | 1890.0 | nM | 5.72 |