Assay Detail
Functional
CHEMBL4189227
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Antiproliferative activity against human SW620 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.62 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257090 | — | — | 1 | 6.64 |
| CHEMBL1257064 | — | — | 1 | 5.72 |
| CHEMBL1257114 | — | — | 1 | 5.07 |
| CHEMBL1257089 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257090 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1257064 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1257114 | — | EC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL1257089 | — | EC50 | = | 8620.0 | nM | 5.06 |