Assay Detail
Functional
CHEMBL4189357
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Antimalarial activity against wild type Plasmodium falciparum Dd2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.08 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | 2.0 | 1 | 9.22 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 8.37 |
| CHEMBL2041980 | MMV-048 | 2.0 | 1 | 8.28 |
| CHEMBL2058836 | — | — | 1 | 8.16 |
| CHEMBL2431810 | — | — | 1 | 7.70 |
| CHEMBL4206746 | — | — | 1 | 7.48 |
| CHEMBL4207489 | SJ-733 | 2.0 | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1956285 | DSM-265 | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL2041980 | MMV-048 | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2058836 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2431810 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4206746 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4207489 | SJ-733 | IC50 | = | 43.0 | nM | 7.37 |