Assay Detail
Binding
CHEMBL4189485
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Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorescent-Labeled Selective Adenosine A2B Receptor Antagonist Enables Competition Binding Assay by Flow Cytometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.07 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483688 | — | — | 1 | 9.13 |
| CHEMBL4215606 | — | — | 1 | 8.97 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.42 |
| CHEMBL4203745 | — | — | 1 | 7.63 |
| CHEMBL16687 | CGS-15943 | — | 1 | 7.22 |
| CHEMBL113142 | ZM-241385 | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483688 | — | IC50 | = | 0.739 | nM | 9.13 |
| CHEMBL4215606 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4203745 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL16687 | CGS-15943 | IC50 | = | 60.7 | nM | 7.22 |
| CHEMBL113142 | ZM-241385 | IC50 | = | 94.9 | nM | 7.02 |