Assay Detail
Binding
CHEMBL4189597
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Inhibition of HIV1 NL4-3 protease assessed as decrease in viral replication in human MT2 cells after 4 days by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.72 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 9.15 |
| CHEMBL4208792 | — | — | 1 | 8.74 |
| CHEMBL4216648 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4208792 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4216648 | — | EC50 | = | 5.3 | nM | 8.28 |