Assay Detail
Functional
CHEMBL4189685
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Antiproliferative activity against human TMD8 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.07 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206284 | — | — | 1 | 8.40 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 8.00 |
| CHEMBL4211949 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4206284 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4211949 | — | IC50 | = | 16.0 | nM | 7.80 |