Assay Detail
Binding
CHEMBL4189737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition measured every 10 secs for 15 mins by fluorometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.41 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584365 | — | — | 1 | 6.15 |
| CHEMBL4210206 | — | — | 1 | 5.70 |
| CHEMBL4214626 | — | — | 1 | 5.40 |
| CHEMBL4203044 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584365 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4210206 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4214626 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4203044 | — | IC50 | = | 40000.0 | nM | 4.40 |