Assay Detail
Binding
CHEMBL4189949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5-HT4E receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.31 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | 1.0 | 1 | 9.59 |
| CHEMBL3306918 | PRX-03140 | 2.0 | 1 | 7.77 |
| CHEMBL117287 | PRUCALOPRIDE | 4.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3306918 | PRX-03140 | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL117287 | PRUCALOPRIDE | EC50 | = | 26.0 | nM | 7.58 |