Assay Detail
Binding
CHEMBL4189991
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measured for 30 mins by fluorescence assay
107
Total Activities
107
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 107 | 7.35 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207222 | — | — | 1 | 8.30 |
| CHEMBL4212671 | — | — | 1 | 8.22 |
| CHEMBL4207514 | — | — | 1 | 8.22 |
| CHEMBL4211904 | — | — | 1 | 8.22 |
| CHEMBL4215704 | — | — | 1 | 8.22 |
| CHEMBL4209722 | — | — | 1 | 8.15 |
| CHEMBL4207617 | — | — | 1 | 8.15 |
| CHEMBL4206606 | — | — | 1 | 8.15 |
| CHEMBL4202680 | — | — | 1 | 8.15 |
| CHEMBL4206272 | — | — | 1 | 8.15 |
| CHEMBL4206892 | — | — | 1 | 8.15 |
| CHEMBL4212891 | — | — | 1 | 8.10 |
| CHEMBL4218688 | — | — | 1 | 8.10 |
| CHEMBL4213848 | — | — | 1 | 8.10 |
| CHEMBL4217115 | — | — | 1 | 8.05 |
| CHEMBL4214724 | — | — | 1 | 8.05 |
| CHEMBL4213604 | — | — | 1 | 8.05 |
| CHEMBL4207953 | — | — | 1 | 8.00 |
| CHEMBL4210671 | — | — | 1 | 8.00 |
| CHEMBL115581 | — | — | 1 | 8.00 |
| CHEMBL4215957 | — | — | 1 | 7.96 |
| CHEMBL4205368 | — | — | 1 | 7.96 |
| CHEMBL4205805 | — | — | 1 | 7.96 |
| CHEMBL4205051 | — | — | 1 | 7.92 |
| CHEMBL4213304 | — | — | 1 | 7.92 |
| CHEMBL4210811 | — | — | 1 | 7.92 |
| CHEMBL4207423 | — | — | 1 | 7.92 |
| CHEMBL4216229 | — | — | 1 | 7.92 |
| CHEMBL4204486 | — | — | 1 | 7.89 |
| CHEMBL4202477 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207222 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4215704 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4207514 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4211904 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4212671 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4209722 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4206892 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4207617 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4206272 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4202680 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4206606 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4212891 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4213848 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4218688 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4214724 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4217115 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4213604 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL115581 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4207953 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4210671 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4205805 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4215957 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4205368 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4213304 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4205051 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4207423 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4210811 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4216229 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4204489 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4214314 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4204486 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4202477 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4208724 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4213024 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4216465 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4203073 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4214162 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4214533 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4209360 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4209616 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1341327 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4214428 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4204849 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4209231 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4203770 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4216402 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4210851 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4210133 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4218208 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4202537 | — | IC50 | = | 21.0 | nM | 7.68 |