Assay Detail
Binding
CHEMBL4189997
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Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSA
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.70 | 5.70 |
| Delta Tm | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206892 | — | — | 2 | 5.70 |
| CHEMBL4206272 | — | — | 2 | 5.70 |
| CHEMBL4214533 | — | — | 1 | 5.70 |
| CHEMBL4207617 | — | — | 1 | 5.70 |
| CHEMBL4212457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214533 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4207617 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4206892 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4206272 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4212457 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4206892 | — | Delta Tm | = | 3.0 | degrees C | - |
| CHEMBL4206272 | — | Delta Tm | = | 3.0 | degrees C | - |