Assay Detail
Functional
CHEMBL4190000
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Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OV-90 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.06 | 5.68 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206892 | — | — | 1 | 5.68 |
| CHEMBL4213848 | — | — | 1 | 5.41 |
| CHEMBL3416562 | — | — | 1 | 5.40 |
| CHEMBL4212457 | — | — | 1 | 5.14 |
| CHEMBL4215649 | — | — | 1 | 4.36 |
| CHEMBL4206272 | — | — | 1 | 4.34 |
| CHEMBL115581 | — | — | 1 | - |
| CHEMBL4216370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4206892 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4213848 | — | EC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL3416562 | — | EC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4212457 | — | EC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL4215649 | — | EC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL4206272 | — | EC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL115581 | — | Activity | - | — | - | |
| CHEMBL4216370 | — | Activity | - | — | - |