Assay Detail
Functional
CHEMBL4191533
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Antiproliferative activity against human 22Rv1 cells expressing androgen receptor splice variants assessed as decrease in cell viability after 5 days by trypan blue exclusion assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Asymmetric 1,5-diarylpenta-1,4-dien-3-ones: Antiproliferative activity in prostate epithelial cell models and pharmacokinetic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.44 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4210606 | — | — | 1 | 6.66 |
| CHEMBL4213439 | — | — | 1 | 6.66 |
| CHEMBL4209057 | — | — | 1 | 6.35 |
| CHEMBL4206838 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4210606 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4213439 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4209057 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4206838 | — | IC50 | = | 850.0 | nM | 6.07 |