Assay Detail
Binding
CHEMBL4191647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RGS17 (unknown origin) GAP activity in presence of GTP by malachite green dye based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Regulator of G-protein signaling 17 (CHEMBL4295974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.90 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 1 | 5.22 |
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | 5.00 |
| CHEMBL417799 | SANGUINARIUM | 2.0 | 1 | 4.92 |
| CHEMBL1438439 | IRIGENOL | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL555017 | GAMBOGIC ACID | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL417799 | SANGUINARIUM | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1438439 | IRIGENOL | IC50 | = | 35000.0 | nM | 4.46 |