Assay Detail
Binding
CHEMBL4191650
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Inhibition of wild type GST-tagged RGS17 (unknown origin) interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Regulator of G-protein signaling 17 (CHEMBL4295974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.48 | 4.98 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 2 | 4.98 |
| CHEMBL1438439 | IRIGENOL | — | 2 | 4.33 |
| CHEMBL417799 | SANGUINARIUM | 2.0 | 2 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1438439 | IRIGENOL | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL417799 | SANGUINARIUM | IC50 | = | 72800.0 | nM | 4.14 |
| CHEMBL417799 | SANGUINARIUM | Inhibition | - | % | - | |
| CHEMBL301982 | CELASTROL | Inhibition | - | % | - | |
| CHEMBL1438439 | IRIGENOL | Inhibition | - | % | - |