Assay Detail
Functional
CHEMBL4191676
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Inhibition of PDGF-BB-induced rat VSMC proliferation preincubated for 30 mins followed by PDGF-BB addition measured after 48 hrs by resazurin assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | VSMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 5.46 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253896 | XANTHOHUMOL | 2.0 | 2 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253896 | XANTHOHUMOL | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL253896 | XANTHOHUMOL | Inhibition | - | % | - |