Assay Detail
Functional
CHEMBL4191830
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Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60(TB) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.48 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209852 | — | — | 1 | 7.25 |
| CHEMBL4214349 | — | — | 1 | 6.99 |
| CHEMBL4214252 | — | — | 1 | 6.84 |
| CHEMBL236789 | MONASTROL | — | 1 | 6.83 |
| CHEMBL4204976 | — | — | 1 | 6.82 |
| CHEMBL4212763 | — | — | 1 | 4.13 |
| CHEMBL4217192 | — | — | 1 | - |
| CHEMBL4209640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209852 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4214349 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4214252 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL236789 | MONASTROL | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4204976 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4212763 | — | IC50 | = | 74400.0 | nM | 4.13 |
| CHEMBL4217192 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL4209640 | — | IC50 | = | 193000.0 | nM | - |