Assay Detail
Binding
CHEMBL4192278
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Inhibition of capsid in HBV infected in human HepAD38 cells assessed as reduction in tetracycline-induced cccDNA formation by measuring reduction in HBe antigen secretion after 14 days by ELISA
14
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis B virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.59 | 6.16 |
| EC90 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3742114 | — | — | 2 | 6.16 |
| CHEMBL4213671 | — | — | 2 | 6.00 |
| CHEMBL1730444 | — | — | 2 | 5.89 |
| CHEMBL4204204 | — | — | 2 | 5.26 |
| CHEMBL4204727 | — | — | 2 | 5.22 |
| CHEMBL4216398 | — | — | 2 | 5.01 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3742114 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4213671 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1730444 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4204204 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4204727 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4216398 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 10000.0 | nM | - |
| CHEMBL5314362 | ENTECAVIR | EC50 | > | 10000.0 | nM | - |
| CHEMBL1730444 | — | EC90 | = | 4.6 | uM | - |
| CHEMBL4213671 | — | EC90 | = | 3.2 | uM | - |
| CHEMBL4204204 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4204727 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4216398 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL3742114 | — | EC90 | = | 1.9 | uM | - |