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Assay Detail

CHEMBL4192283

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HBV infected in human HepAD38 cells assessed as reduction in extracellular viral DNA level by RT-PCR method
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis B virus (CHEMBL613497)
Type ORGANISM
Organism Hepatitis B virus

Publication

Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.
Sari O, Boucle S, Cox BD, Ozturk T, Russell OO, Bassit L, Amblard F, Schinazi RF.
Eur J Med Chem (2017) 138 : 407 -421
PubMed 28688280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 6.44 9.15
EC90 8 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5314362 ENTECAVIR 4.0 2 9.15
CHEMBL141 LAMIVUDINE 4.0 2 7.40
CHEMBL3742114 2 6.70
CHEMBL1730444 2 6.10
CHEMBL4213671 2 5.92
CHEMBL4204727 2 5.68
CHEMBL4216398 2 5.43
CHEMBL4204204 2 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5314362 ENTECAVIR EC50 = 0.7 nM 9.15
CHEMBL141 LAMIVUDINE EC50 = 40.0 nM 7.40
CHEMBL3742114 EC50 = 200.0 nM 6.70
CHEMBL1730444 EC50 = 800.0 nM 6.10
CHEMBL4213671 EC50 = 1200.0 nM 5.92
CHEMBL4204727 EC50 = 2100.0 nM 5.68
CHEMBL4216398 EC50 = 3700.0 nM 5.43
CHEMBL4204204 EC50 = 6900.0 nM 5.16
CHEMBL1730444 EC90 = 7.8 uM -
CHEMBL4213671 EC90 = 6.3 uM -
CHEMBL4204204 EC90 > 10.0 uM -
CHEMBL4204727 EC90 = 9.5 uM -
CHEMBL4216398 EC90 >= 10.0 uM -
CHEMBL141 LAMIVUDINE EC90 = 0.3 uM -
CHEMBL5314362 ENTECAVIR EC90 = 0.1 uM -
CHEMBL3742114 EC90 = 1.0 uM -