Assay Detail
Functional
CHEMBL4192492
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Antiproliferative activity against human Maver1 cells after 72 hrs by CellTiter Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Maver1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.57 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4202879 | — | — | 1 | 6.52 |
| CHEMBL4207231 | — | — | 1 | 5.75 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 5.29 |
| CHEMBL4214539 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4202879 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4207231 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4214539 | — | IC50 | = | 18500.0 | nM | 4.73 |