Assay Detail

CHEMBL4192782

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Binding

Inhibition of BACE1 (unknown origin)

ChEMBL ↗

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Target

Beta-secretase 1 (CHEMBL4822) ↗

Open DB target context

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Beta-secretase 1 (CHEMBL4822) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-secretase 1

CHEMBL4822

Anchored from Assay target.

Protein identity Beta-secretase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-secretase 1 (CHEMBL4822) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.

Azimi S, Zonouzi A, Firuzi O, Iraji A, Saeedi M, Mahdavi M, Mahdavi M, Edraki N.
Eur J Med Chem (2017) 138 : 729 -737
PubMed 28728105 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.40	9.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3301601	VERUBECESTAT	3.0	1	9.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3301601	VERUBECESTAT	IC50	=	0.4	nM	9.40