Assay Detail
Functional
CHEMBL4193099
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.71 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.82 |
| CHEMBL4215396 | — | — | 1 | 5.38 |
| CHEMBL4207542 | — | — | 1 | 5.15 |
| CHEMBL4216154 | — | — | 1 | 5.04 |
| CHEMBL4213804 | — | — | 1 | 4.97 |
| CHEMBL4216220 | — | — | 1 | 4.92 |
| CHEMBL4218730 | — | — | 1 | 4.83 |
| CHEMBL4210975 | — | — | 1 | 4.79 |
| CHEMBL4206886 | — | — | 1 | 4.76 |
| CHEMBL4202778 | — | — | 1 | 4.75 |
| CHEMBL4211258 | — | — | 1 | 4.74 |
| CHEMBL4203717 | — | — | 1 | 4.69 |
| CHEMBL4215930 | — | — | 1 | 4.62 |
| CHEMBL4210262 | — | — | 1 | 4.60 |
| CHEMBL4211771 | — | — | 1 | 4.58 |
| CHEMBL4214436 | — | — | 1 | 4.56 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.54 |
| CHEMBL4211708 | — | — | 1 | 4.53 |
| CHEMBL4203206 | — | — | 1 | 4.50 |
| CHEMBL4206821 | — | — | 1 | 4.48 |
| CHEMBL4212449 | — | — | 1 | 4.45 |
| CHEMBL4211189 | — | — | 1 | 4.39 |
| CHEMBL4207344 | — | — | 1 | 4.37 |
| CHEMBL4202989 | — | — | 1 | 4.37 |
| CHEMBL4211700 | — | — | 1 | 4.36 |
| CHEMBL4214656 | — | — | 1 | 4.33 |
| CHEMBL4203061 | — | — | 1 | - |
| CHEMBL4202455 | — | — | 1 | - |
| CHEMBL4215193 | — | — | 1 | - |
| CHEMBL4202528 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4215396 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4207542 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4216154 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4213804 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4216220 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4218730 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4210975 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4206886 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4202778 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4211258 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4203717 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4215930 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4210262 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL4211771 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL4214436 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4211708 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL4203206 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4206821 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL4212449 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL4211189 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL4207344 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL4202989 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL4211700 | — | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL4214656 | — | IC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL4203061 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4202455 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4215193 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4202528 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL12850 | DEHYDROABIETIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL4207416 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4214716 | — | IC50 | > | 50000.0 | nM | - |