Assay Detail
Binding
CHEMBL4193524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF colorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.72 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213353 | — | — | 1 | 9.30 |
| CHEMBL1765463 | — | — | 1 | 8.96 |
| CHEMBL4207685 | — | — | 1 | 8.42 |
| CHEMBL4207150 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213353 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1765463 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4207685 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4207150 | — | IC50 | = | 6.5 | nM | 8.19 |