Assay Detail
Functional
CHEMBL4193526
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Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-HEP1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.12 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213353 | — | — | 1 | 6.96 |
| CHEMBL4209490 | — | — | 1 | 6.77 |
| CHEMBL4204888 | — | — | 1 | 6.52 |
| CHEMBL4211787 | — | — | 1 | 6.52 |
| CHEMBL4207685 | — | — | 1 | 6.40 |
| CHEMBL4207150 | — | — | 1 | 6.22 |
| CHEMBL4208968 | — | — | 1 | 6.12 |
| CHEMBL4208539 | — | — | 1 | 6.10 |
| CHEMBL4211001 | — | — | 1 | 6.09 |
| CHEMBL4204625 | — | — | 1 | 6.08 |
| CHEMBL4203662 | — | — | 1 | 6.01 |
| CHEMBL1765463 | — | — | 1 | 5.96 |
| CHEMBL4218882 | — | — | 1 | 5.85 |
| CHEMBL4217764 | — | — | 1 | 5.69 |
| CHEMBL4215962 | — | — | 1 | 5.65 |
| CHEMBL4206626 | — | — | 1 | 4.94 |
| CHEMBL4218288 | — | — | 1 | - |
| CHEMBL4214461 | — | — | 1 | - |
| CHEMBL4207809 | — | — | 1 | - |
| CHEMBL4215272 | — | — | 1 | - |
| CHEMBL4210337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213353 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4209490 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4204888 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4211787 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4207685 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4207150 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4208968 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4208539 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4211001 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4204625 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4203662 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1765463 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4218882 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4217764 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4215962 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4206626 | — | IC50 | = | 11490.0 | nM | 4.94 |
| CHEMBL4218288 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4214461 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4207809 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4215272 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4210337 | — | IC50 | > | 20000.0 | nM | - |