Assay Detail
Functional
CHEMBL4193529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.33 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213353 | — | — | 1 | 7.40 |
| CHEMBL4218882 | — | — | 1 | 7.00 |
| CHEMBL4207150 | — | — | 1 | 7.00 |
| CHEMBL4207809 | — | — | 1 | 6.70 |
| CHEMBL4214461 | — | — | 1 | 6.70 |
| CHEMBL4209490 | — | — | 1 | 6.64 |
| CHEMBL1765463 | — | — | 1 | 6.58 |
| CHEMBL4204888 | — | — | 1 | 6.52 |
| CHEMBL4218288 | — | — | 1 | 6.40 |
| CHEMBL4208539 | — | — | 1 | 6.32 |
| CHEMBL4207685 | — | — | 1 | 6.30 |
| CHEMBL4203662 | — | — | 1 | 6.30 |
| CHEMBL4215272 | — | — | 1 | 6.29 |
| CHEMBL4211001 | — | — | 1 | 6.24 |
| CHEMBL4208968 | — | — | 1 | 5.94 |
| CHEMBL4217764 | — | — | 1 | 5.79 |
| CHEMBL4215962 | — | — | 1 | 5.59 |
| CHEMBL4204625 | — | — | 1 | 5.45 |
| CHEMBL4206626 | — | — | 1 | 5.12 |
| CHEMBL4211787 | — | — | 1 | - |
| CHEMBL4210337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213353 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4218882 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4207150 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4207809 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4214461 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4209490 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1765463 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4204888 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4218288 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4208539 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4207685 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4203662 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4215272 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4211001 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4208968 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4217764 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4215962 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4204625 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4206626 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4211787 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4210337 | — | IC50 | > | 20000.0 | nM | - |