Assay Detail
ADMET
CHEMBL4193530
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Cytotoxicity against against HUVEC after 72 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.34 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213353 | — | — | 1 | 5.53 |
| CHEMBL4207685 | — | — | 1 | 5.45 |
| CHEMBL4207150 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213353 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4207685 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4207150 | — | IC50 | = | 8970.0 | nM | 5.05 |