Assay Detail
Binding
CHEMBL4193552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of electric eel AChE assessed as inhibition constant for enzyme inhibitor complex preincubated for 20 mins followed by acetylthiocholine iodide substrate addition and measured for 30 mins at 1 min intervals by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.46 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 6.43 |
| CHEMBL4207493 | — | — | 1 | 5.69 |
| CHEMBL4214790 | — | — | 1 | 5.50 |
| CHEMBL4211036 | — | — | 1 | 5.47 |
| CHEMBL4210163 | — | — | 1 | 5.29 |
| CHEMBL4212392 | — | — | 1 | 5.17 |
| CHEMBL4204224 | — | — | 1 | 5.13 |
| CHEMBL4207906 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4207493 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL4214790 | — | Ki | = | 3160.0 | nM | 5.50 |
| CHEMBL4211036 | — | Ki | = | 3410.0 | nM | 5.47 |
| CHEMBL4210163 | — | Ki | = | 5090.0 | nM | 5.29 |
| CHEMBL4212392 | — | Ki | = | 6830.0 | nM | 5.17 |
| CHEMBL4204224 | — | Ki | = | 7450.0 | nM | 5.13 |
| CHEMBL4207906 | — | Ki | = | 9990.0 | nM | 5.00 |