Assay Detail
Binding
CHEMBL4193553
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Competitive inhibition of electric eel AChE assessed as inhibition constant for enzyme-substrate-inhibitor complex preincubated for 20 mins followed by acetylthiocholine iodide substrate addition and measured for 30 mins at 1 min intervals by Ellman's method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.42 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212392 | — | — | 1 | 4.64 |
| CHEMBL4207493 | — | — | 1 | 4.63 |
| CHEMBL4214790 | — | — | 1 | 4.38 |
| CHEMBL4207906 | — | — | 1 | 4.34 |
| CHEMBL4211036 | — | — | 1 | 4.09 |
| CHEMBL4204224 | — | — | 1 | - |
| CHEMBL4210163 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212392 | — | Ki | = | 22990.0 | nM | 4.64 |
| CHEMBL4207493 | — | Ki | = | 23320.0 | nM | 4.63 |
| CHEMBL4214790 | — | Ki | = | 41480.0 | nM | 4.38 |
| CHEMBL4207906 | — | Ki | = | 45410.0 | nM | 4.34 |
| CHEMBL4211036 | — | Ki | = | 81850.0 | nM | 4.09 |
| CHEMBL4204224 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4210163 | — | Ki | > | 50000.0 | nM | - |