Assay Detail
Binding
CHEMBL4193573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat Kv1.3 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 3 (CHEMBL4248) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.09 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397591 | OROIDIN | — | 1 | 6.09 |
| CHEMBL4213446 | — | — | 1 | - |
| CHEMBL4208517 | — | — | 1 | - |
| CHEMBL4202870 | — | — | 1 | - |
| CHEMBL4207745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397591 | OROIDIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4213446 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4208517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4202870 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4207745 | — | IC50 | > | 10000.0 | nM | - |