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Assay Detail

CHEMBL4193695

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of hydrogen potassium ATPase in goat stomach mucosal membrane assessed as decrease in inorganic phosphate production using ATP as substrate after 10 to 15 mins by spectrophotometric analysis
25
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Capra hircus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Substituted methoxybenzyl-sulfonyl-1H-benzo[d]imidazoles evaluated as effective H+/K+-ATPase inhibitors and anti-ulcer therapeutics.
Rajesh R, Manikandan A, Sivakumar A, Ramasubbu C, Nagaraju N.
Eur J Med Chem (2017) 139 : 454 -460
PubMed 28818769 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.15 6.91
Ki 12 7.60 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4208061 2 7.60
CHEMBL4209529 2 7.60
CHEMBL4204672 2 7.60
CHEMBL4205978 2 7.60
CHEMBL4210863 2 7.60
CHEMBL4218223 2 7.60
CHEMBL4206495 2 7.60
CHEMBL4204247 2 7.60
CHEMBL4215909 2 7.60
CHEMBL4217389 2 7.60
CHEMBL4212434 2 7.60
CHEMBL4212971 2 7.60
CHEMBL1503 OMEPRAZOLE 4.0 1 6.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4208061 Ki = 25.0 nM 7.60
CHEMBL4212971 Ki = 25.0 nM 7.60
CHEMBL4212434 Ki = 25.0 nM 7.60
CHEMBL4217389 Ki = 25.0 nM 7.60
CHEMBL4215909 Ki = 25.0 nM 7.60
CHEMBL4204247 Ki = 25.0 nM 7.60
CHEMBL4218223 Ki = 25.0 nM 7.60
CHEMBL4210863 Ki = 25.0 nM 7.60
CHEMBL4209529 Ki = 25.0 nM 7.60
CHEMBL4205978 Ki = 25.0 nM 7.60
CHEMBL4204672 Ki = 25.0 nM 7.60
CHEMBL4206495 Ki = 25.0 nM 7.60
CHEMBL4205978 IC50 = 124.0 nM 6.91
CHEMBL4206495 IC50 = 198.0 nM 6.70
CHEMBL4215909 IC50 = 228.0 nM 6.64
CHEMBL4218223 IC50 = 355.0 nM 6.45
CHEMBL4210863 IC50 = 814.0 nM 6.09
CHEMBL4204247 IC50 = 918.0 nM 6.04
CHEMBL1503 OMEPRAZOLE IC50 = 980.0 nM 6.01
CHEMBL4212434 IC50 = 1151.0 nM 5.94
CHEMBL4204672 IC50 = 1292.0 nM 5.89
CHEMBL4217389 IC50 = 1355.0 nM 5.87
CHEMBL4209529 IC50 = 1456.0 nM 5.84
CHEMBL4208061 IC50 = 1656.0 nM 5.78
CHEMBL4212971 IC50 = 1682.0 nM 5.77