Assay Detail
Functional
CHEMBL4193720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human EBC1 cells after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EBC-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.65 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208236 | — | — | 1 | 7.60 |
| CHEMBL4214018 | — | — | 1 | 7.38 |
| CHEMBL4207111 | — | — | 1 | 7.34 |
| CHEMBL4204833 | — | — | 1 | 7.24 |
| CHEMBL3417489 | — | — | 1 | 7.22 |
| CHEMBL4203363 | — | — | 1 | 7.10 |
| CHEMBL4209189 | — | — | 1 | 6.92 |
| CHEMBL4209174 | — | — | 1 | 6.68 |
| CHEMBL4210834 | — | — | 1 | 6.68 |
| CHEMBL4205747 | — | — | 1 | 6.43 |
| CHEMBL4209005 | — | — | 1 | 6.43 |
| CHEMBL4204322 | — | — | 1 | 6.35 |
| CHEMBL4204308 | — | — | 1 | 6.34 |
| CHEMBL4207710 | — | — | 1 | 6.31 |
| CHEMBL4218410 | — | — | 1 | 6.19 |
| CHEMBL4209562 | — | — | 1 | 6.06 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.89 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 5.54 |
| CHEMBL4216512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208236 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4214018 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4207111 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4204833 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3417489 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4203363 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4209189 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4209174 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4210834 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4205747 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4209005 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4204322 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4204308 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4207710 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4218410 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4209562 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4216512 | — | IC50 | > | 10000.0 | nM | - |